How Genetically "Human" Are Any of Us?

[DIGEST: IFLS, Tufts Now, Sci News, The Science Explorer, Ars Technica]

How human are you? New research shows that more than 8% of our genetic makeup isn’t our own: it comes from viruses. Some of that viral DNA may have been passed down from our ancestors for at least 670,000 years.

And in 50 of the 2500 people examined, this includes a full genetic recipe for an entire virus.

“This is a thrilling discovery,” says study lead author Dr. Julia Wildschutte of the University of Michigan Medical School. “It will open up many doors to research.”

DNADr. Julia Wildschutte. (CREDIT: Source)

The study, by a team working at Tufts University and the University of Michigan Medical School, looked at the entire span of DNA from people around the world. They compared key areas of each person’s genome to a digitized genetic sequence assembled by scientists to act as a representative sample of our species’ DNA.

What they found were 19 new human endogenous retroviruses (HERVs). These new HERVs are part of the endogenous retrovirus family HERV-K. The study also confirmed 17 HERVs that had been previously identified.

HERVs are DNA versions of RNA-based viruses that permanently lodge their code into human DNA. Most retroviruses become fragmented and mutate as they pass down through

generations. Some retroviruses, when activated, can cause diseases such as HIV, or adapt to work with the human body, like the HERV sequence that helps protect a developing fetus from toxins in its mother’s blood.

“These are remnants of ancient events that have not been fixed in the population as a whole, but rather happened in the ancestors of some people alive today,” says University of Michigan genetics researcher Jeffrey Kidd, Ph.D. “There have been a number of examples of other HERVs that insert themselves next to human genes or near them, and have impact on their expression. We’re interested in applying these methods to find other types of viral or mobile element insertions.”

Jeffrey Kidd. (CREDIT: Source.)

“Many studies have tried to link these endogenous viral elements to cancer and other diseases,” says Zachary H. Williams, Ph.D, co-author of the study, “but a major difficulty has been that we haven't actually found all of them yet.”

The big news: the study discovered a fully intact viral genome. Provirus Xq21 is only the second intact provirus found in human DNA, and it was found in 2% of the study’s participants.

“A lot of the most interesting elements are only found in a small percentage of people,” says Williams, “which means you have to screen a large number of people to find them.”

It’s not yet clear whether provirus Xq21 can replicate or reproduce, but the study’s coordinating author, Tufts University School of Medicine virologist John Coffin, is hopeful that it can help scientists learn more about ancient disease. “This one looks like it is capable of making infectious virus, which would be very exciting if true, as it would allow us to study a viral epidemic that took place long ago,” he said in a statement.

Mark Wilson/Getty Images

President Donald Trump took the opportunity to hype his pet project—bollard fencing along the southern border—to a meeting of the National Border Patrol Council.

The NBPC—a union organization not part of the federal agency—is "the exclusive representative of approximately 18,000 Border Patrol Agents and support personnel assigned to the U.S. Border Patrol."

Keep reading...
Rich Polk/Getty Images for IMDb // Drew Angerer/Getty Images

Veteran actor and Democrat Alec Baldwin's portrayal of President Donald Trump on Saturday Night Live has garnered near-unanimous praise since the 2016 campaign (except, of course, from Trump himself).

But in a recent tweet, Baldwin reminded his followers that Trump's ascent and increasing corruption is no laughing matter.

Keep reading...
Fox Business

President Donald Trump's personal lawyer and one of the key players in the Ukraine scandal, Rudy Giuliani, is once again claiming to have proof of a Democratic scandal in Ukraine.

Once again, he's refusing to reveal it.

Keep reading...
Fox Business

Attorney General William Barr criticized President Donald Trump's tweets about Justice Department prosecutors' sentencing recommendation for Trump ally Roger Stone.

Barr—who overrode the recommendation after Trump railed against it on Twitter—said Trump's tweets made it impossible to do his job, though some people believe his words weren't to rein in Trump, but to mitigate public outrage.

Fox Host Lou Dobbs is not one of those people.

Keep reading...
Leah Millis-Pool/Getty Images // Chip Somodevilla/Getty Imageseditsharetrending_up

Americans across the country were furious when President Donald Trump fired Lieutenant Colonel Alexander Vindman after Trump was acquitted in his impeachment trial by the Republican Senate.

Vindman complied with a congressional subpoena to testify before the House committee overseeing Trump's impeachment inquiry last year.

The career military official and Purple Heart recipient was escorted out by security along with his twin brother, an NSC official who played no part in the impeachment proceedings.

Keep reading...
ABC News

People cried foul earlier this week when the Justice Department overrode four career prosecutors to recommend a reduced sentence for former Trump campaign advisor Roger Stone.

The Department's decision came only a day after Trump railed against the prosecutors' recommendation on Twitter, leading many to believe the Department reduced the sentence recommendation because the President interceded on his ally's behalf.

All four prosecutors on the case resigned in response to the change.

Keep reading...