In September 2015, Martin Shkreli, the hedge fund manager and CEO of Turing Pharmaceuticals, caused widespread outrage when he obtained the manufacturing license for a drug known as Daraprim and raised its price 5,000 percent, from $13.50 to $750 per tablet. Daraprim, a generic drug known as pyrimethamine that is on the World Health Organization’s list of essential medicines, was originally created 62 years ago as an antimalarial medication, but has since been found to be effective in treating infections caused by toxoplasmosis, especially in people with HIV and cancer patients undergoing chemotherapy treatment. Shkreli’s audacious move underscored the potential for price-gouging by pharmaceutical companies.
The situation inspired Alice Williamson, a post-doctoral teaching fellow at the University of Sydney in Australia who works with the Open Source Malaria Consortium, to assign a group of 11th-graders at Sydney Grammar School to recreate the drug. The Open Source Malaria Consortium is a project that aims to show how science can be improved when data and results are shared. “Why don’t we see if we can try to get the boys to make this medicine?” she said.
They did. Using less than U.S. $30 worth of materials purchased online, the students were able to replicate a very pure 3.7 grams of pyrimethamine, otherwise known as Daraprim. The current value of that quantity of the medicine would be $100,000. Williamson said the Shkreli scandal impressed upon the students the importance of sharing scientific data surrounding life-saving treatments, and the “real-life” nature of the experiment gave more focus to their work in the chemistry lab. They were able to study the patented route to creating the drug, although they did not follow it, due to safety issues involved with some of the reagents used in the original formula. The students created a new, safer pathway to achieve the same result. In the spirit of openness, the group has shared the entire process online.
The experiment also shows how dramatic the markup can be in the pharmaceutical business. Another important treatment, the EpiPen, also saw a price hike from around
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